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Related Experiment Video

Updated: Apr 6, 2026

qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
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KIR3DS1*0130109: a novel activating three-domain KIR identified using sequence-based typing.

L Wang1,2, Y Zhang3, T Dong4

  • 1Capital Medical University, Beijing Ditan Hospital, Beijing, China.

Tissue Antigens
|July 23, 2015
PubMed
Summary
This summary is machine-generated.

The KIR3DS1*0130109 gene variant is nearly identical to KIR3DS1*0130101. The only difference is a single nucleotide change from Adenine to Guanine within intron 4.

Keywords:
AsiaKIR3DS1long-range sequencingnew allele

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Area of Science:

  • * Immunology
  • * Genetics

Background:

  • * Killer cell immunoglobulin-like receptors (KIRs) are crucial regulators of immune responses.
  • * KIR gene polymorphisms influence immune cell function and disease susceptibility.

Purpose of the Study:

  • * To characterize the genetic differences between KIR3DS1*0130109 and KIR3DS1*0130101 alleles.
  • * To identify specific mutations that may affect KIR3DS1 gene function.

Main Methods:

  • * Comparative sequence analysis of KIR3DS1 alleles.
  • * Identification of single nucleotide polymorphisms (SNPs) and their locations.

Main Results:

  • * KIR3DS1*0130109 shares high sequence homology with KIR3DS1*0130101.
  • * A specific A > G nucleotide substitution was identified in intron 4 of KIR3DS1*0130109.

Conclusions:

  • * The primary distinction between KIR3DS1*0130109 and KIR3DS1*0130101 lies in a single intronic SNP.
  • * Further research is needed to determine the functional impact of this intronic variation on KIR3DS1 expression or function.