Hypoglycaemic activity of carbothioamides and related 1,2,4-thiodiazolidines

¹Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.

Farmaco (Societa Chimica Italiana : 1989)

|October 1, 1989

Abstract:

N-[imino(ethyl ethylidine hydrazine)methyl]-N-aryl-2- amino-carbothioamidine hydrochlorides with ethylmethylketothiosemicarbazone in acetone medium at 0-5 degrees C. The carbothioamides were oxidized by H2O2 to 1,2,4-thiodiazolidine derivatives. The 4-Cl derivative in both the series was the most active hypoglycaemic agent. The compounds lowered mean blood sugar levels (MBSL) by 38.81% (compound 2, Table II) and 15.19% (compound 2, Table III) respectively after 24 hours of drug treatment. The compounds also showed antidiabetic activity in alloxan diabetic rats.

Related Experiment Videos

Hypoglycaemic activity of carbothioamides and related 1,2,4-thiodiazolidines

Related Concept Videos

1,2,4-triazine analogs as novel class of therapeutic agents.

Design and Synthesis of Some Novel 4-(4-substituted aryl) Semicarbazones as Anticonvulsant Agents.

Synthesis and anticonvulsant activity of some substituted 1,2,4-thiadiazoles.

Combretastatin a-4 analogs as anticancer agents.

4-sulphamoylphenyl semicarbazones with anticonvulsant activity.

Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone.

Chemical and biochemical transformations of 5-ethoxycarbonyl-5-phenyl-2-isoxazolines.

Nasal administration of heparin-loaded microspheres based on poly(lactic acid).

New 8-substituted xanthiene derivatives as potent bronchodilators.

In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies.

Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties.

Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines.

The Beekeeping Sector of Kazakhstan and Contributions to the Pharmaceutical Industry: Promising Flavonoids with the Pharmacokinetic Properties Via the Computational Evaluations.

Berbamine Alleviates Chronic Inflammatory Pain via Microglial Inhibition and Oxidative Stress Reduction in the Anterior Cingulate Cortex.

A Novel Indole-Dihydroisoxazole Compound Activates Apoptotic, Mitochondrial and Autophagy-related Responses in Lymphoid and Myeloid Leukemia Cells.

Anagrelide remodels the PDE3A-SLFN12 interactome to associate with translation initiation machinery in cancer cell lines.

Tautomeric asymmetric self-inhibition: an underexploited pH-dependent strategy to enhance berberrubine solubility.

Serotonergic psychedelics and amphetamine shift male rat ultrasonic vocalizations toward call patterns associated with positively valenced states.

Related Experiment Videos

Hypoglycaemic activity of carbothioamides and related 1,2,4-thiodiazolidines

Abstract:

Related Concept Videos

Related Articles