Related Experiment Video
Updated: Apr 6, 2026
3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
Toxoplasma gondii seropositivity is negatively associated with multiple sclerosis
Frauke Stascheit1, Friedemann Paul2, Lutz Harms1
1Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany.
Background:
Toxoplasma (T.) gondii is a ubiquitous intracellular parasitic protozoan that was recently associated with various autoimmune diseases.
Objectives:
We aimed to investigate the prevalence of T. gondii IgG and IgM antibodies between MS patients and healthy controls.
Methods:
Sera from 163 MS, 91 clinically isolated syndrome cases and 178 age and gender matched controls were evaluated for the prevalence of T. gondii IgG antibodies utilizing chemiluminescent immunoassay (ARCHITECT).
Results:
MS-patients showed a significantly lower prevalence for T. gondii IgG antibodies compared to controls (33.3% vs. 47.9%; p=0.011, OR=1.8 (95% CI 1.2-3.2)).
Conclusion:
The results demonstrate a negative association between an infection with the parasite T. gondii and the presence of MS.
More Related Videos
11:21Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
Published on: March 12, 2015
09:56Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
Published on: August 12, 2010