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Updated: Apr 6, 2026
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
[Expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and the clinicopathological implications]
Xiufen Li1, Anli Hou, Zhenhuan Li
1Department of Gynecology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.E-mail: lixiuf120@163.com.
Objective:
To investigate the expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and explore the clinicopathological implications.
Methods:
Immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) were used to detect the expressions of SFRP4 and DKK1 in 66 cervical squamous cell carcinoma and 26 normal cervical specimens.
Results:
SFRP4 expression was significantly higher (P<0.01) and DKK1 expression was significantly lower (P<0.05) in the carcinoma tissues than in normal cervical tissues. DKK1 was negatively correlated with SFRP4 in the carcinoma tissues (P<0.01), and their expressions were associated with the clinical stages, tumor differentiation, depth of invasion and lymph node metastasis of the tumors (P<0.05).
Conclusion:
SFRP4 and DKK1, the upstream components of the Wnt pathway, play a key role in the tumorigenesis of cervical squamous cell carcinoma, and their expressions are associated with the clinicopathological features of the malignancy.
