Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal influences on glial progenitor cell development.

J M Levine1

  • 1Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794.

Neuron
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Putative Cerebral Microbleeds in Dogs Undergoing Magnetic Resonance Imaging of the Head: A Retrospective Study of Demographics, Clinical Associations, and Relationship to Case Outcome.

Journal of veterinary internal medicine·2017
Same author

Clinical Features and Magnetic Resonance Imaging Findings in 7 Dogs with Central Nervous System Aspergillosis.

Journal of veterinary internal medicine·2015
Same author

Hyperacute Vasospasm After Aneurysmal Subarachnoid Hemorrhage.

Neurocritical care·2015
Same author

Red Blood Cell Distribution Width is Associated with Poor Clinical Outcome After Subarachnoid Hemorrhage: A Pilot Study.

Neurocritical care·2015
Same author

Quantitative magnetic resonance imaging in a naturally occurring canine model of spinal cord injury.

Spinal cord·2015
Same author

Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury.

Gene therapy·2014

Neuronal factors influence glial progenitor cell development. Specifically, signals from young cerebellar interneurons promote oligodendrocyte differentiation in optic nerve progenitor cells, impacting lineage decisions.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Bipotential glial progenitor cells are crucial for central nervous system development.
  • Cell-cell interactions and microenvironmental cues significantly influence progenitor cell fate.
  • Oligodendrocyte differentiation timing is tightly regulated.

Purpose of the Study:

  • To investigate the role of cell-cell interactions in glial progenitor cell development.
  • To determine how neuronal factors affect oligodendrocyte differentiation.
  • To understand the influence of the neuronal microenvironment on glial lineage decisions.

Main Methods:

  • Cultures of rat cerebellum and optic nerve progenitor cells were utilized.
  • Progenitor cell division rates and differentiation were monitored.

Related Experiment Videos

  • Analysis of factors secreted by cerebellar interneurons and their effects on optic nerve progenitor cells.

    • Main Results:

    • Cerebellar progenitor cells exhibit slow division, with progeny often remaining progenitors.
    • Postconfluent cerebellar progenitor cells differentiate into oligodendrocytes in serum-free medium.
    • Factors from young cerebellar interneurons stimulate optic nerve progenitor cell proliferation and survival.
    • These neuronal factors appear to modulate the timing of oligodendrocyte differentiation.

    Conclusions:

    • The neuronal microenvironment plays a critical role in directing glial progenitor cell lineage.
    • Interneuron-derived factors can override intrinsic timing mechanisms for oligodendrocyte differentiation.
    • Cell-cell communication is essential for regulating glial cell development and fate determination.