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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Ulcerative Colitis Database: An Integrated Database and Toolkit for Gene Function and Medication Involved in

Jun Shen1, Ai-Ping Mao, Ming Ming Zhu

  • 1*Department of Gastroenterology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai IBD Research Center, Shanghai, China; †Committee on Immunology, Department of Pathology, The University of Chicago, Chicago, Illinois; ‡Center for Growth, Metabolism and Aging, School of Life Sciences, Sichuan University, Chengdu, China; §Department of Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; and ||Department of Medicine, The University of Chicago, Chicago, Illinois.

Inflammatory Bowel Diseases
|July 23, 2015
PubMed
Summary

A new Ulcerative Colitis Database (UCDB) consolidates genomic data, genes, drugs, and loci, offering analysis tools for ulcerative colitis (UC) research. This resource aids basic and clinical studies for the UC community.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Immunology

Background:

  • Extensive genomic data exists for ulcerative colitis (UC) pathogenesis and therapies.
  • A centralized, comprehensive repository for this UC data is currently lacking.

Purpose of the Study:

  • To construct a comprehensive database and analysis toolkit for ulcerative colitis (UC) research.
  • To integrate curated information on UC-related genes, drugs, and genetic loci.

Main Methods:

  • The Ulcerative Colitis Database (UCDB) was built using text mining and manual curation of scientific literature.
  • UC DNA microarray data were collected and analyzed using R packages for gene expression analysis.

Main Results:

  • UCDB comprises UC GENE (1151 genes from 2919 publications), UC DRUG (248 drugs from 2344 publications), and UC LOCUS (110 SNP loci).
  • Includes an expression quantitative trait loci browser and UC ANALYSIS toolkit for 37 datasets (1098 samples), supporting correlation, clustering, and GSEA.

Conclusions:

  • UCDB offers a curated collection of UC-related genes and drugs with accessible gene expression analysis tools.
  • This database serves as a valuable resource for basic and clinical research, benefiting the global ulcerative colitis community.