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Updated: Apr 6, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
Published on: July 29, 2014
A Sense of Self: RIG-I's Tolerance to Host RNA
1Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Abstract:
The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.
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