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Escaping Negative Selection: ILC You in the Gut
Adam M Farkas1, Ivaylo I Ivanov1
1Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Immunity
|July 23, 2015
Abstract:
How commensal-specific T cells are controlled in the periphery is poorly understood. In a recent issue of Science, Hepworth et al. (2015) show that ILC3s induce apoptosis of microbiota-specific CD4 T cells in a form of extrathymic negative selection.