Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Types and frequencies of adverse events across clinical trials for patients with amyotrophic lateral sclerosis: an analysis of the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same author

Clinical and Demographic Predictors of Optic Neuritis Subtype.

Neuro-ophthalmology (Aeolus Press)·2026
Same author

Artificial Intelligence-Based Prognostic Models for Postoperative Outcomes in Vitreoretinal Surgery: A Systematic Review and Meta-Analysis.

Ophthalmology. Retina·2026
Same author

Visual Field Testing: The Key to Localizing Afferent Visual Pathway Lesions.

Neurologic clinics·2026
Same author

Microstructure-informed deep learning improves thalamic atrophy segmentation and clinical associations in multiple sclerosis and related neuroimmunological diseases.

NeuroImage. Clinical·2026
Same author

Healthcare Provider Perspectives on the Assessment and Management of Cerebral Visual Impairment in Children.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026

Related Experiment Video

Updated: Apr 6, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.6K

RETINAL LESION EVOLUTION IN SUSAC SYNDROME.

Alexander U Brandt1, Timm Oberwahrenbrock, Fiona Costello

  • 1*NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany; †Departments of Clinical Neurosciences, and ‡Surgery, University of Calgary, Calgary, Alberta, Canada; §Calgary Retina Consultants, University of Calgary, Calgary, Alberta, Canada; ¶Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany; **Department of Neurology, University of Münster, Münster, Germany; and ††Department of Ophthalmology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Retina (Philadelphia, Pa.)
|July 23, 2015
PubMed
Summary
This summary is machine-generated.

Retinal lesions in Susac syndrome show distinct stages of development, involving artery occlusion, hypoxic damage, and axonal degeneration. Understanding these changes aids in diagnosing visual loss in neuroinflammatory conditions.

More Related Videos

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
11:03

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

10.6K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.4K

Related Experiment Videos

Last Updated: Apr 6, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.6K
Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
11:03

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

10.6K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.4K

Area of Science:

  • Ophthalmology
  • Neuroimmunology
  • Vascular Biology

Background:

  • Susac syndrome is a rare neuroinflammatory disorder affecting the brain, retina, and inner ear.
  • Retinal involvement in Susac syndrome can lead to significant visual impairment.

Purpose of the Study:

  • To characterize the evolution of retinal lesions in Susac syndrome across acute, postacute, and late disease phases.
  • To elucidate the underlying mechanisms of retinal damage in Susac syndrome.

Main Methods:

  • High-resolution spectral domain optical coherence tomography (SD-OCT) and retinal fluorescein angiography (FA) were utilized.
  • A cross-sectional study of four patients and a longitudinal case study of one patient were conducted.

Main Results:

  • Retinal lesions in Susac syndrome exhibit four distinct sections: primary occlusion, hypoxic damage, and axonal degeneration.
  • Lesion morphology evolves over time, with distinct sections merging and showing progressive degeneration of retinal layers in later stages.

Conclusions:

  • The complex lesion development suggests mechanisms beyond simple immune reaction and hypoxia.
  • Characteristic lesion morphology aids in diagnosing acute visual loss in Susac syndrome.
  • Further studies are needed to confirm specificity in differentiating from other retinal vascular diseases.