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Comparison of ferrous sulfate, polymaltose complex and iron-zinc in iron deficiency anemia

Yasemin Ozsurekci1, Sule Unal2, Mualla Cetin2

  • 1Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey - yas.oguz99@yahoo.com.

Minerva Pediatrica
|July 23, 2015
PubMed

Insights

Ferrous sulfate, iron polymaltose complexes, and combined iron and zinc are effective in treating iron deficiency anemia (IDA) in children. All treatments significantly improved hemoglobin levels over eight weeks with no significant differences between groups.

Area of Science:

  • Pediatric Hematology
  • Nutritional Anemia
  • Pharmacological Interventions

Background:

  • Iron deficiency anemia (IDA) is a prevalent nutritional disorder in children globally.
  • Effective oral iron supplementation is crucial for managing pediatric IDA.
  • Comparing different oral iron formulations is essential for optimizing treatment strategies.

Purpose of the Study:

  • To compare the efficacy of three distinct oral iron preparations in treating iron deficiency anemia (IDA) in pediatric patients.
  • To evaluate the impact of ferrous sulfate (Fe-S), iron polymaltose complexes (Fe-OH-PM), and a combined iron and zinc preparation (Fe-Zn) on hematological parameters.
  • To determine the optimal oral iron formulation for children diagnosed with IDA.

Main Methods:

  • A randomized controlled trial involving sixty children diagnosed with IDA (aged 6 months to 180 months).
  • Participants were assigned to one of three treatment groups: Fe-S, Fe-OH-PM, or Fe-Zn.
  • Hemoglobin and other hematological markers were assessed at baseline and at weeks 1, 4, and 8 of the 8-week treatment period.

Main Results:

  • All three oral iron preparations led to statistically significant increases in hemoglobin (Hgb) levels by weeks 4 and 8 compared to baseline (P<0.001).
  • No statistically significant differences in Hgb levels were observed between the Fe-S, Fe-OH-PM, and Fe-Zn groups at the conclusion of the 8-week treatment period (P>0.05).
  • Hematological parameters showed consistent improvement across all treatment arms.

Conclusions:

  • Iron polymaltose complexes (Fe-OH-PM) and combined iron and zinc (Fe-Zn) preparations are effective alternatives to ferrous sulfate (Fe-S) for treating IDA in children.
  • These findings suggest that Fe-OH-PM and Fe-Zn can be considered viable therapeutic options alongside Fe-S for pediatric IDA.
  • The study supports the use of multiple oral iron formulations for managing IDA in pediatric populations.
Abstract

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