Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet-activating factor in human luteal phase endometrium.

A A Alecozay1, B G Casslén, R M Riehl

  • 1Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284.

Biology of Reproduction
|October 1, 1989
PubMed
Summary

Platelet-activating factor (PAF) is present in the human endometrium, with glandular cells producing it in response to hormonal stimulation. This finding suggests PAF

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Educating food handlers.

Canadian journal of public health = Revue canadienne de sante publique·2010
Same author

A new phospholipide-splitting enzyme specific for the ester linkage between the nitrogenous base and the phosphoric acid grouping.

The Journal of biological chemistry·2010
Same author

The phosphorus-containing lipides of the carrot.

The Journal of biological chemistry·2010
Same author

Low frequency ultrasonic propagation through fibre reinforced, polymer composites.

Ultrasonics·2002
Same author

Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial.

European journal of clinical nutrition·2002
Same author

Leukemia inhibitory factor, leukemia inhibitory factor receptor, and glycoprotein 130 in rhesus monkey uterus during menstrual cycle and early pregnancy.

Biology of reproduction·2000

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Cell Biology

Background:

  • Platelet-activating factor (PAF) is a potent mediator of vascular permeability.
  • PAF levels fluctuate in the rabbit endometrium before implantation, indicating a potential role in early pregnancy signaling.

Purpose of the Study:

  • To investigate the presence and cellular origin of PAF in the human endometrium.
  • To determine the hormonal regulation of endometrial PAF production.

Main Methods:

  • Human endometrial tissue was obtained during the luteal phase.
  • Stromal and epithelial glandular cells were isolated and cultured.
  • PAF activity was assessed using bioassays after lipid extraction and chromatography.

Main Results:

Related Experiment Videos

  • Epithelial glandular cells produced significantly more prostaglandin F (PGF) than stromal cells.
  • Estradiol and progesterone plus estradiol increased PGF release from glandular cells.
  • Stromal cells secreted prolactin, which was modulated by progesterone.

Conclusions:

  • PAF is present in the human endometrium.
  • Endometrial PAF production is likely regulated by hormones, with glandular cells being a potential source.
  • Further research is needed to elucidate PAF's precise role in human implantation.