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Related Concept Videos

Extracellular Matrix01:26

Extracellular Matrix

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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The Extracellular Matrix01:29

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
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Proteomics01:33

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
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Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications.

Chia Wei Chang1, Ailsa J Dalgliesh1, Javier E López2

  • 1Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA.

Proteomics. Clinical Applications
|July 23, 2015
PubMed
Summary

Investigating the cardiac extracellular matrix (ECM) proteome is difficult but crucial for understanding heart disease. New proteomic methods enable detailed analysis for improved cardiac repair and regeneration strategies.

Keywords:
Cardiac diseasesDecellularizationExtracellular matrix biomarkerExtracellular matrix remodelingExtracellular proteomics

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Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Proteomics

Background:

  • The extracellular matrix (ECM) is a dynamic component of tissues, involved in signaling during development, injury, and disease.
  • Cardiac ECM proteomic analysis is challenging due to protein insolubility, post-translational modifications, complex formation, and interference from abundant cellular proteins.

Purpose of the Study:

  • To highlight the challenges and recent advancements in cardiac extracellular matrix (ECM) proteomic analysis.
  • To emphasize the potential of ECM proteomics in understanding cardiac disease and guiding therapeutic development.

Main Methods:

  • Review of recent techniques for enriching and analyzing extracellular matrix (ECM) proteins.
  • Discussion of the application of cardiac ECM proteomics in disease contexts.

Main Results:

  • Recent technological advancements are facilitating the study of the cardiac ECM proteome.
  • Cardiac ECM proteomics offers valuable spatial and temporal insights into disease processes.

Conclusions:

  • Overcoming the challenges in cardiac ECM proteomics is key to advancing diagnostics and therapeutics.
  • ECM proteomics holds significant promise for cardiac repair and regeneration strategies.