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Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers

Seung-Taek Lim1, Seok-Ki Min2, Yoo-Chan Kwon1

  • 1College of Sport Science, Dong-A University, Busan, South Korea.

Atherosclerosis
|July 23, 2015
PubMed

Insights

Intermittent exercise significantly reduced key markers of arterial wall remodeling, including cathepsins and adhesion molecules, in night shift workers. This suggests exercise may prevent atherosclerosis and improve cardiovascular health.

Area of Science:

  • Cardiovascular Science
  • Exercise Physiology
  • Biochemistry

Background:

  • Arterial wall remodeling involves elastases like Cathepsin L (CatL) and Cathepsin S (CatS).
  • Adhesion molecules such as monocyte chemotactic protein-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin) are implicated in atherosclerosis.
  • Night shift work is associated with increased cardiovascular disease risk.

Purpose of the Study:

  • To investigate the impact of intermittent exercise on plasma concentrations of CatL, CatS, MCP-1, sVCAM-1, and sE-selectin.
  • To assess the effectiveness of intermittent exercise in mitigating cardiovascular disease risk factors in night shift workers.

Main Methods:

  • A 10-week study involving 30 male night shift workers, divided into experimental (n=15) and control (n=15) groups.
  • The experimental group engaged in intermittent exercise (30 min/day, 3 days/week).
  • Measurements included body composition, blood pressure, and plasma levels of specific cathepsins and adhesion molecules.

Main Results:

  • Significant reductions in body weight and body fat percentage were observed in the exercise group.
  • Intermittent exercise led to significant decreases in plasma CatL, CatS, MCP-1, sE-selectin, and sVCAM-1 levels.
  • These changes indicate a positive impact on cardiovascular disease risk factors.

Conclusions:

  • Intermittent exercise demonstrates potential as an intervention to prevent atherosclerosis in night shift workers.
  • Regular exercise may improve cardiovascular health by modulating key markers of arterial wall remodeling.
  • Further research is warranted to confirm these preliminary findings.
Abstract

Keywords:
Adhesion moleculesCathepsin KCathepsin LCathepsin SIntermittent exerciseNight shift worker

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