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Updated: Apr 6, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
Published on: October 10, 2011
Model systems and clinical applications of hepatic stem cells for liver regeneration
Min Zhang1, Yan Zhong1, Jun Chen2
1Liver Diseases Center, The Second Xiangya Hospital, Changsha, 410011, China.
Background:
Hepatic stem cells are capable to self-renew and to differentiate into all types of cells in the liver, including hepatic progenitors, mature hepatocytes and cholangiocytes.
Aims:
This review summarizes the recent advances in animal studies and the results of clinical trials over the last few decades.
Results:
Studies in numerous animal models of liver diseases have demonstrated the efficacy of hepatic stem cells. Clinical studies of hepatic stem cells are also promising for a variety of hepatic diseases.
Conclusions:
With the accumulation of innovative and creative works, hepatic stem cells therapy will be a new approach for liver diseases.
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