Related Experiment Video
Updated: Apr 6, 2026
08:41
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
1.9K
Angiogenesis: a phenomenon which aggravates chronic liver disease progression
1Department of Physiology in Zabrze, Medical University of Silesia in Katowice, Ul. Jordana 19, 41-800, Zabrze, Poland. kuklamich@poczta.onet.pl.
Hepatology International
|July 24, 2015
Summary
Angiogenesis, the formation of new blood vessels, is crucial in chronic liver diseases like hepatitis C and fatty liver disease. Understanding this process aids in evaluating disease progression and identifying new therapeutic targets.
Area of Science:
- Hepatology and Vascular Biology
- Chronic Liver Disease Pathogenesis
Background:
- Angiogenesis and fibrogenesis are key contributors to chronic wound healing and disease progression.
- In liver disease, angiogenesis involves pathological vascular remodeling, leading to impaired blood flow and liver function.
- The roles of angiogenesis in chronic hepatitis C and nonalcoholic fatty liver disease require further elucidation.
Purpose of the Study:
- To describe the pathogenesis of new blood vessel formation in chronic hepatitis.
- To explore the potential role of angiogenesis in the progression of chronic liver diseases.
Main Methods:
- Review of current literature on hepatic angiogenesis and fibrogenesis.
- Analysis of pathological mechanisms in chronic liver conditions.
Main Results:
- Physiological hepatic angiogenesis supports liver regeneration.
- Pathological angiogenesis in the liver includes sinusoidal capillarization and intrahepatic shunts.
- These changes increase hepatic resistance and reduce hepatocyte perfusion.
Conclusions:
- Angiogenesis is a critical factor in the progression of chronic liver diseases.
- Targeting angiogenesis may offer new therapeutic strategies for liver conditions.
Keywords:
AdipokineAngiogenesisChronic hepatitis CFibrosisHepatic stellate cellInflammatory activityLiverNonalcoholic fatty liver diseaseMore Related Videos
Related Concept Videos
01:24Liver Regeneration
5.0K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
5.0K
01:24Regulation of Angiogenesis and Blood Supply
4.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
337
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
337
01:17Gastritis-II: Pathophysiology
1.8K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.8K
01:10Mechanism of Angiogenesis
7.7K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.7K
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
257
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
257