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Updated: Apr 6, 2026
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 codon 72 polymorphism and hepatocellular carcinoma: a meta-analysis.
Shuting Jia1, Wenru Tang2, Ying Luo2
1Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 727 Jing Ming Nan Road, Chenggong County, Kunming, 650500, Yunnan, China. lilith-jia@hotmail.com.
This meta-analysis indicates that the p53 codon 72 Pro/Pro genotype is linked to a higher risk of hepatocellular carcinoma (HCC) in Caucasian populations. Further global research is recommended to confirm this association between p53 polymorphism and HCC.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Hepatocellular carcinoma (HCC) is a prevalent malignancy globally.
- The p53 tumor suppressor gene, frequently mutated in HCC, has a known Arg72Pro polymorphism.
- The prognostic significance of p53 mutations and the Arg72Pro variant in HCC remains uncertain.
Purpose of the Study:
- To evaluate the association between the p53 Arg72Pro polymorphism and the risk of HCC.
- To investigate the link between this polymorphism and HCC specifically in patients infected with HBV/HCV.
Main Methods:
- A systematic literature search of PubMed was performed to identify relevant studies.
- Studies with available genotype frequencies for the p53 Arg72Pro polymorphism were included.
- Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association.
Main Results:
- Ten studies comprising 1,371 HCC cases and 2,517 controls were analyzed.
- Overall, variant genotypes (Pro/Pro) were associated with an increased HCC risk (OR 1.355, p=0.024).
- Stratified analysis revealed a significantly increased HCC risk in Caucasians with the Pro/Pro genotype under a recessive model (OR 1.927, p=0.017).
- No association was found between the p53 codon 72 polymorphism and HBV/HCV-positive HCC.
- Publication bias was assessed and found to be minimal.
Conclusions:
- The p53 codon 72 Pro/Pro genotype is associated with an elevated risk of HCC in Caucasian individuals.
- Further large-scale international studies are necessary to validate this association and explore the polymorphism's role in HCC development.
