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Changes in Oxygen Partial Pressure in the Vitreous Body and Arterial Blood of Rabbits Depending on Oxygen
L I Amkhanitskaya1, G V Nikolaeva, N A Sokolova
1Department of Ophthalmology, Faculty of Pediatrics, N. I. Pirogov Russian National Research Medical University, Moscow, Russia, eidos_eidosovich@mail.ru.
Abstract:
We demonstrated that the vitreous body of one-month-old rabbits becomes a "reservoir" for storage and accumulation of oxygen after exposure to additional oxygenation of the organism (O2 concentrations in inspired gas mixture were 40, 60, 85, and 99%). The higher was O2 concentration in inspired mixture, the higher was oxygen saturation of the blood and vitreous body. O2 concentration of 40% was relatively safe for eye tissues. O2 concentration >60% induced oxygen accumulation in the vitreous body, which can be a provoking factor for the development of oxygen-induced pathologies.
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