[Glomuvenous malformations]
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Updated: Apr 6, 2026
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
N Spindler1, S Hanske2, K Schierle3
1Klinik für Orthopädie, Unfallchirurgie und Plastische Chirurgie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland. nick.spindler@medizin.uni-leipzig.de.
Symptoms:
A patient presented suffering from neural pain in the medial foot for a period of over 20 years.
Diagnosis:
Diagnostic showed a widely spread soft-tissue tumor consisting of confluent glomuvenous malformations that was responsible for the immense pain syndrome.The solitary or multiform-appearing knots are not compressible and manifest as the characteristic syndromes of regional pain, sensitivity to coldness, or local pressure pain. Alternatively, the patient could also be completely symptom-free.
Treatment:
Because of the dimension of the tumor and the degree of suffering, a radical resection with simultaneous microsurgical reconstruction was carried out. Twelve weeks postoperatively, healing of the flap stabilized, the foot is fully weight-bearing, and the patient is pain-free.
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