Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Experimental goiter formation].

J F Denef

    Bulletin Et Memoires De L'Academie Royale De Medecine De Belgique
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Iodine excess causes thyroid damage in goiter, leading to cell death and inflammation. This toxicity, linked to free radicals, can be mitigated by adjusting iodine levels or using specific treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Destruction of contrast microbubbles by ultrasound: effects on myocardial function, coronary perfusion pressure, and microvascular integrity.

    Circulation·2001
    Same author

    Neural morphological effects of long-term implantation of the self-sizing spiral cuff nerve electrode.

    Medical & biological engineering & computing·2001
    Same author

    Duplex PCR for differential identification of Mycobacterium bovis, M. avium, and M. avium subsp. paratuberculosis in formalin- fixed paraffin-embedded tissues from cattle.

    Journal of clinical microbiology·2000
    Same author

    Evidence for co-ordinated changes between vascular endothelial growth factor and nitric oxide synthase III immunoreactivity, the functional status of the thyroid follicles, and the microvascular bed during chronic stimulation by low iodine and propylthiouracyl in old mice.

    European journal of endocrinology·2000
    Same author

    Automatic morphometry of nerve histological sections.

    Journal of neuroscience methods·2000
    Same author

    Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.

    The Journal of clinical investigation·2000
    Same journal

    [Belgium Royal Academy of Medicine membership list].

    Bulletin et memoires de l'Academie royale de medecine de Belgique·2015
    Same journal

    Massively parallel sequencing: a new tool in virus discovery and vaccine safety.

    Bulletin et memoires de l'Academie royale de medecine de Belgique·2012
    Same journal

    New viral pathogens from wildlife.

    Bulletin et memoires de l'Academie royale de medecine de Belgique·2012
    Same journal

    Liver transplantation or Starzl's legacy. A look backward, a look forward.

    Bulletin et memoires de l'Academie royale de medecine de Belgique·2012
    Same journal

    [The creation of a vascularized tracheal transplantation].

    Bulletin et memoires de l'Academie royale de medecine de Belgique·2012
    Same journal

    [Molecular dialogue between African trypanosomes and humans].

    Bulletin et memoires de l'Academie royale de medecine de Belgique·2012
    See all related articles

    Area of Science:

    • Endocrinology
    • Pathology
    • Toxicology

    Context:

    • Goiter pathogenesis and nodule formation remain poorly understood, lacking adequate animal models.
    • Iodine's role in thyroid heterogeneity and cold follicle development is established.
    • Excessive iodine administration in goitrous mice reveals specific pathological changes.

    Purpose:

    • To investigate the effects of iodide excess on goitrous mice.
    • To understand the mechanisms underlying iodide-induced thyroid toxicity and inflammation.
    • To identify potential protective strategies against iodide-induced thyroid damage.

    Summary:

    • Administration of excess iodide to goitrous mice induced significant follicle cell necrosis and thyroiditis.
    • These pathological effects were preventable by reducing iodine dosage, administering thyroid hormones (T3/T4), or using antithyroid drugs or vitamin E.

    Related Experiment Videos

  • Evidence suggests iodide toxicity is mediated by excessive free radical production, with increased Ia-positive interstitial cells observed during inflammation.

    • Impact:

    • Provides a valuable animal model for studying goiter nodule formation and thyroiditis.
    • Elucidates the role of iodine excess and oxidative stress in thyroid pathology.
    • Suggests therapeutic strategies for managing iodide-induced thyroid damage and inflammation.