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Safety and efficacy of abciximab in older adults undergoing percutaneous coronary intervention

R A Brown1, E Shantsila1,2, C Varma2

  • 1University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.

International Journal of Clinical Practice
|July 24, 2015
PubMed

Insights

Abciximab use in older adults undergoing percutaneous coronary intervention (PCI) was evaluated. The drug appears safe and effective, showing no significant increase in bleeding or mortality risks for elderly patients.

Area of Science:

  • Cardiology
  • Geriatric Medicine
  • Pharmacology

Background:

  • Older patients are underrepresented in abciximab use during percutaneous coronary intervention (PCI) due to cost and bleeding concerns.
  • This underutilization may stem from perceived higher risks in the elderly population.

Purpose of the Study:

  • To assess the safety and efficacy of abciximab in patients aged 75 years and older undergoing PCI.
  • To compare bleeding, ischaemic events, and mortality rates between older and younger patients receiving abciximab.

Main Methods:

  • Retrospective, observational, single-center cohort study.
  • Utilized the British Cardiovascular Intervention Society (BCIS) database.
  • Analyzed data from 5727 consecutive patients undergoing PCI between January 2008 and June 2014, with a focus on 1298 older patients (≥ 75 years).

Main Results:

  • Older patients (23% of cohort) received abciximab less frequently (15% vs. 22% in younger patients).
  • Unadjusted analysis showed higher bleeding and mortality rates in older patients.
  • Multivariate analysis indicated that abciximab use in older patients was not significantly associated with increased bleeding, ischaemic outcomes, or in-hospital mortality.

Conclusions:

  • Abciximab may be safely used in older adults undergoing PCI when indicated.
  • The drug does not appear to be associated with excess bleeding complications in the elderly compared to younger individuals.
Abstract

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