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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
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Prediction of Cell-Penetrating Peptides
Mattias Hällbrink1, Mati Karelson
1Department of Neurochemistry, Stockholm University, Stockholm, Sweden.
Methods in Molecular Biology (Clifton, N.J.)
|July 24, 2015
Abstract:
The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is demonstrated on the basis of the exemplary cases from the literature.

