Related Experiment Video
Updated: Aug 14, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics
Ping Zhang1, Lidija Covic, Athan Kuliopulos
1Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Tufts University School of Medicine, Box 7510, 800 Washington Street, Boston, MA, 02111, USA.
Abstract:
Lipopeptides based on the intracellular loops of cell-surface receptors, known as "Pepducins," represent a promising new class of compounds used for the study of membrane proteins and as potential therapeutics in a variety of diseases. Detailed knowledge of the three-dimensional structure of G-protein-coupled receptors (GPCRs) and delineation of the mechanisms of pepducin activation and biased G-protein signaling has facilitated the development of even more potent pepducin allosteric modulators.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Inhibitors of Gram-positive Cell Wall Synthesis

