Genetic polymorphism of miR-146a is associated with gastric cancer risk: a meta-analysis

Several studies have investigated the associations between miR-146a rs2910164 and gastric cancer (GC) risk, but results have been inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. PubMed and China National Knowledge Infrastructure searches were carried out for relevant studies published before July 2014. Meta-analysis was performed with the stata, version 11.0. A total of seven case-control studies, including 3283 cases and 4535 controls, were selected. A significant association was found between rs2910164 and GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66-0.87; CC vs. GC+GG, OR = 0.84, 95% CI = 0.71-0.99; CC+GC vs. GG, OR = 0.82, 95% CI = 0.73-0.91) for the total data. In the subgroup analysis by ethnicity, statistically significant association was found in Asian. This meta-analysis suggested that the miR-146a rs2910164 was a risk factor for developing GC.