Related Experiment Video
Updated: Aug 6, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
[IgG subclasses in the serum and circulating immune complexes in patients with Kawasaki disease]
Abstract:
IgG subclass levels in sera of 17 patients with Kawasaki disease were determined and a significant increase of IgG 1 (P less than 0.001) and IgG 3 (P less than 0.001) was found in the patients compared with 22 age-matched healthy children, while IgG 2 and IgG 4 were normal or slightly decreased. IgG immune complexes were measured by SPA-ELISA combined with PEG precipitations, and 8 out of 17 patients (47.1%) were found to have CIC values above the normal control range (geometric mean +2 SD). IgG subclass composition in CIC was analysed. The subclasses in CIC were predominantly in IgG 1 and IgG 3. Because the antibody responses to different antigens have IgG subclass restriction. These results suggest that the change of serum and CIC IgG subclasses in Kawasaki disease may be related to the pathogenesis of the disease.
More Related Videos
11:10Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Related Concept Videos
Humoral Immune Responses
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Immunocytochemistry and Immunohistochemistry
These...
Antibody Actions
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Hypersensitivity Reactions: Immune-Complex Reactions