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Interobserver reproducibility of the controlled attenuation parameter (CAP) for quantifying liver steatosis
Giovanna Ferraioli1, Carmine Tinelli2, Raffaella Lissandrin3
1Ultrasound Unit, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Via Taramelli 5, 27100, Pavia, Italy. giovanna.ferraioli@unipv.it.
Hepatology International
|July 24, 2015
Summary
Controlled attenuation parameter (CAP) measurements show good interobserver agreement. In healthy individuals, CAP is strongly correlated with age and body mass index (BMI), but not gender.
Area of Science:
- Medical imaging
- Hepatology
- Non-invasive diagnostics
Background:
- Controlled attenuation parameter (CAP) is a non-invasive method to assess liver steatosis.
- Interobserver reproducibility is crucial for reliable clinical application of CAP measurements.
Purpose of the Study:
- To prospectively evaluate the interobserver reproducibility of CAP measurements.
- To investigate the relationship between CAP values and body mass index (BMI), gender, and age.
Main Methods:
- Prospective study involving 351 subjects using the FibroScan M+ probe.
- Measurements were performed by two independent raters.
- Interobserver agreement assessed using concordance correlation coefficient (CCC); correlations analyzed using Pearson r and linear regression.
Main Results:
- Overall CCC for CAP measurements was 0.82, indicating good interobserver agreement.
- Agreement varied by BMI categories, with lower agreement in subjects with BMI ≥30 kg/m² (CCC=0.65).
- CAP values showed a strong correlation with age and BMI (p<0.05), but not with gender.
Conclusions:
- Interreader agreement for CAP measurements is good, supporting its reliability.
- Age and BMI are significant independent predictors of CAP values in healthy volunteers.
