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Updates in pediatric venous thromboembolism

Mirinda A Gillespie1, Courtney A Lyle, Neil A Goldenberg

  • 1aOffice of Medical Education, All Children's Hospital Johns Hopkins Medicine, St. Petersburg, Florida bDepartment of Pediatrics, Billings Clinic, Billings, Montana cJHM Pediatric Thrombosis Program, All Children's Hospital Johns Hopkins Medicine, St. Petersburg, Florida dJohns Hopkins Children's Center eDepartment of Pediatrics, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Current Opinion in Hematology
|July 24, 2015
PubMed

Insights

Pediatric venous thromboembolism (VTE) research is rapidly advancing, with new risk factors and treatments emerging. This review highlights recent findings and ongoing clinical trials in pediatric VTE prevention and management.

Area of Science:

  • Pediatric Hematology
  • Thrombosis Research
  • Clinical Trials

Background:

  • Pediatric venous thromboembolism (VTE) incidence and complications are rising.
  • Understanding VTE epidemiology and risk factors in children is crucial.

Purpose of the Study:

  • To review recent evidence on pediatric VTE epidemiology, risk factors, and scores.
  • To summarize findings from pediatric VTE prevention and treatment studies.
  • To provide an update on ongoing clinical trials in pediatric VTE.

Main Methods:

  • PubMed-based literature review (August 2014 - March 2015).
  • Searches of clinicaltrials.gov and EudraCT databases (March 2015).

Main Results:

  • Established and validated risk factors and models for pediatric VTE.
  • Studies on fondaparinux and dalteparin pharmacokinetics, safety, and efficacy.
  • Pilot data from a randomized trial on anticoagulation duration.
  • 14 pediatric clinical trials for oral direct anticoagulants registered.

Conclusions:

  • Significant progress and activity in pediatric VTE research.
  • Ongoing advancements in understanding and managing pediatric VTE.
  • Numerous registered clinical trials indicate a dynamic field.
Abstract

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