Related Experiment Video
Updated: Apr 6, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Coefficient of Friction of Human Corneal Tissue
Tawnya Wilson1, Rudolf Aeschlimann, Samuele Tosatti
1*Johnson & Johnson Vision Care, Inc, Jacksonville, FL; and †SuSoS AG, Dübendorf, Switzerland.
Purpose:
A novel property evaluation methodology was used to determine the elusive value for the human corneal coefficient of friction (CoF).
Methods:
Using a microtribometer on 28 fresh human donor corneas with intact epithelia, the CoF was determined in 4 test solutions (≥5 corneas/solution): tear-mimicking solution (TMS) in borate-buffered saline (TMS-PS), TMS in phosphate-buffered saline (TMS-PBS), TMS with HEPES-buffered saline (TMS-HEPES), and tear-like fluid in PBS (TLF-PBS).
Results:
Mean (SD) CoF values ranged from 0.006 to 0.015 and were 0.013 (0.010) in TMS-PS, 0.006 (0.003) in TMS-PBS, 0.014 (0.005) in TMS-HEPES, and 0.015 (0.009) in TLF-PBS. Statistically significant differences were shown for TMS-PBS versus TLF (P = 0.0424) and TMS-PBS versus TMS-HEPES (P = 0.0179), but not for TMS-PBS versus TMS-PS (P = 0.2389).
Conclusions:
Successful measurement of the fresh human corneal tissue CoF was demonstrated, with values differing in the evaluated buffer solutions, within this limited sample size.
Related Concept Videos
01:21Characteristics of Dry Friction
Before the wheelbarrow starts moving, the static frictional force acts tangentially to the contact surface, opposing the force that is about to induce the motion. This frictional force prevents the...
01:07Frictional Force
01:30Dry Friction
To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...