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Updated: Apr 6, 2026
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Thyroid autoantibodies and the effect on pregnancy outcomes
S Nazarpour1, F Ramezani Tehrani, M Simbar
1Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Summary
Thyroid antibody positivity in euthyroid pregnant women may negatively impact pregnancy outcomes. More research is needed to determine if Levothyroxine treatment improves outcomes for these women.
Area of Science:
- Endocrinology
- Obstetrics
- Immunology
Background:
- Thyroid antibody positivity is common in women.
- Links between thyroid antibodies and pregnancy complications are studied, but Levothyroxine treatment effects are unclear.
Purpose of the Study:
- To review the impact of treating euthyroid pregnant women with autoimmune thyroid disease and positive thyroid antibodies on pregnancy outcomes.
Main Methods:
- Systematic review with a prospective protocol.
- Searched PubMed, Science direct, Google Scholar, Embase, and Cochrane Library databases up to January 2014.
- Included English manuscripts meeting pre-stated criteria.
Main Results:
- Inadequate data exists on the adverse effects of thyroid antibody positivity in euthyroid women on pregnancy outcomes.
- Limited data is available on the effects of Levothyroxine treatment in these women.
- Most studies suggest adverse effects of thyroid antibody positivity in euthyroid women on pregnancy outcomes.
Conclusions:
- More randomized clinical trials are necessary.
- Investigate the effects of treating pregnant euthyroid women with positive thyroid antibodies on maternal and neonatal outcomes.
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