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[Amerindian admixture estimation based on serological and molecular methods]
Revista Medica De Chile
|July 24, 2015
Summary
Amerindian admixture estimates in Chile can be reliably determined using ABO*A blood group alleles as an alternative to ancestral identity markers (AIMs), especially with larger sample sizes. This finding aids in accurate case and control selection for epidemiological studies.
Area of Science:
- Population Genetics
- Human Ancestry
- Epidemiology
Background:
- Amerindian admixture is crucial for epidemiological studies in the Americas.
- Accurate admixture estimation is vital for proper case and control selection.
Purpose of the Study:
- To compare Amerindian admixture estimates using ABO*A and ABO*O blood group alleles versus ancestral identity markers (AIMs).
- To evaluate the utility of ABO alleles as a proxy for AIMs in the Chilean population.
Main Methods:
- Determined Amerindian admixture rates in 720 Chilean volunteers.
- Utilized ABO*O and ABO*A alleles and 40 AIMs (SNPs) for estimation.
Main Results:
- Mean admixture estimates were 35% (ABO*O), 47% (ABO*A), and 48% (AIMs).
- Generally good concordance was observed between methods, with a notable exception between ABO*O and AIMs.
Conclusions:
- ABO*A allele-based admixture estimates can serve as a viable alternative to AIMs in Chile for large sample sizes.
- This approach can facilitate more precise epidemiological research in admixed populations.
