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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

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[Fecal microbiota transplantation in recurrent Clostridium difficile infection. Report of one case]

Felipe Moscoso, Daniela Simian, Daniela Rivera

    Revista Medica De Chile
    |July 24, 2015
    PubMed

    Insights

    Fecal microbiota transplantation (FMT) offers high success for recurrent Clostridium difficile infection. A case study shows FMT effectively resolved persistent diarrhea after multiple vancomycin treatments in a 57-year-old woman.

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Infectious Diseases

    Background:

    • Recurrent Clostridium difficile infection (CDI) poses a significant clinical challenge.
    • Antibiotic-associated diarrhea can lead to severe gastrointestinal distress.
    • Standard treatments like vancomycin may fail in refractory CDI cases.

    Observation:

    • A 57-year-old woman experienced recurrent CDI despite three courses of vancomycin.
    • The patient presented with antibiotic-associated diarrhea confirmed by positive Clostridium difficile toxin PCR.
    • Persistent symptoms necessitated exploring alternative therapeutic strategies.

    Findings:

    • Fecal microbiota transplantation (FMT) was performed using a relative's stool, instilled into the distal ileum.
    • The patient achieved a good clinical response following FMT.
    • Diarrhea resolved completely, with no recurrence observed during a 6-month follow-up period.

    Implications:

    • FMT demonstrates high efficacy in treating recurrent and refractory Clostridium difficile infections.
    • This case highlights FMT as a viable and successful therapeutic option when conventional treatments fail.
    • Successful FMT can restore gut microbiome balance, leading to sustained clinical improvement and preventing relapse.

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