Related Experiment Video

Updated: Apr 6, 2026

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
08:24

Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment

Published on: May 25, 2020

7.6K

Therapeutic potential of resveratrol in heart failure

Miranda M Sung1, Jason R B Dyck1

  • 1Department of Pediatrics, Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

Annals of the New York Academy of Sciences
|July 25, 2015
PubMed

Insights

Resveratrol, a natural compound, shows promise in animal studies for treating heart failure by improving cardiac function and survival. It also benefits skeletal muscle and vascular health, potentially enhancing quality of life for heart failure patients.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Heart failure significantly impacts patient quality of life and survival rates.
  • Existing therapies offer limited efficacy, necessitating novel treatment strategies.
  • Resveratrol, a polyphenol from plants, is being investigated for its cardioprotective effects.

Purpose of the Study:

  • To evaluate the potential of resveratrol as a therapeutic agent for heart failure.
  • To assess resveratrol's impact on cardiac function, survival, and peripheral tissue alterations in heart failure models.

Main Methods:

  • Review of animal studies investigating resveratrol administration in various heart failure models.
  • Analysis of resveratrol's effects on cardiac performance, mortality, skeletal muscle function, and vascular health.

Main Results:

  • Resveratrol administration prevented or slowed heart failure progression in multiple animal models.
  • Studies indicated improved cardiac function and survival with resveratrol treatment in established heart failure.
  • Resveratrol demonstrated beneficial effects on skeletal muscle and endothelial/vascular function, addressing key heart failure symptoms.

Conclusions:

  • Animal studies suggest resveratrol possesses therapeutic potential for heart failure.
  • Resveratrol may offer a novel treatment strategy by improving cardiac and peripheral tissue function.
  • Further research is warranted to determine if these findings translate to human heart failure patients.
Keywords:
AMPKexerciseheart failureremodelingresveratrol

More Related Videos

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

9.0K
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.1K

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.4K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
557
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
588
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
1.2K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.2K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.4K