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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Related Experiment Video

Updated: Apr 6, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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RNA (Epi)genetics in cardiovascular diseases.

Leonardo Elia1, Gianluigi Condorelli2

  • 1Humanitas Clinical and Research Center, Via Manzoni 113, 20089 Rozzano, MI, Italy; Milan Unit, Institute of Genetic and Biomedical Research, Via Manzoni 113, 20089 Rozzano, MI, Italy.

Journal of Molecular and Cellular Cardiology
|July 25, 2015
PubMed
Summary

Non-coding RNAs (ncRNAs) regulate gene expression and are implicated in cardiovascular diseases. Understanding microRNAs and long non-coding RNAs offers insights into disease mechanisms and potential therapies.

Keywords:
Cardiovascular diseasesLong non-coding RNAsMicroRNAsRNA therapeutics

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Area of Science:

  • Genomics
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Next-generation sequencing has revealed numerous non-coding RNAs (ncRNAs) with regulatory functions.
  • Dysregulation of ncRNAs is linked to various pathologies, notably cardiovascular diseases.
  • MicroRNAs (miRNAs) are well-studied ncRNAs involved in gene expression inhibition and cardiovascular disease.

Purpose of the Study:

  • To provide an overview of ncRNA functions in cardiovascular disease development.
  • To focus on the roles of microRNAs and long non-coding RNAs (lncRNAs) in cardiovascular pathologies.
  • To highlight the need for detailed characterization of ncRNA mechanisms for therapeutic development.

Main Methods:

  • Literature review and synthesis of current knowledge on ncRNAs.
  • Focus on established roles of microRNAs in cardiovascular regulation.
  • Exploration of emerging research on long non-coding RNAs in cardiovascular disease.

Main Results:

  • ncRNAs play significant regulatory roles in mammalian gene expression.
  • Specific ncRNAs, particularly miRNAs, are implicated in the pathogenesis of cardiovascular diseases.
  • The complex mechanisms of lncRNAs in cardiovascular disease require further investigation.

Conclusions:

  • Understanding ncRNA function is crucial for deciphering cardiovascular disease mechanisms.
  • Detailed characterization of ncRNA action can lead to novel therapeutic strategies.
  • Further research into lncRNAs is warranted for their role in cardiovascular health and disease.