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Updated: Apr 6, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

Exosomes: Implications in HIV-1 Pathogenesis.

Marisa N Madison¹, Chioma M Okeoma^2,3

¹Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. marisa-madison@uiowa.edu.

|July 25, 2015

Summary

Exosomes, tiny vesicles carrying cellular material, influence human immunodeficiency virus type 1 (HIV-1) infection. Their effects depend on the exosome source, offering potential therapeutic strategies against HIV-1 transmission.

Keywords:

HIV-1 exosome extracellular vesicle murine AIDS nanoparticle semen seminal plasma

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Last Updated: Apr 6, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Area of Science:

Extracellular vesicles research
Virology and immunology
Cellular biology and signaling

Background:

Exosomes are nanovesicles involved in intercellular communication, transporting diverse molecular cargos.
These vesicles play roles in both normal physiological processes and various diseases, including viral infections.
The specific impact of exosomes on viral pathogenesis is an emerging area of study.

Purpose of the Study:

To review the multifaceted roles of exosomes in human immunodeficiency virus type 1 (HIV-1) pathogenesis.
To explore how HIV-1 infection is modulated by exosomes from different cellular sources.
To examine the reciprocal interaction where HIV-1 factors target exosomes.

Main Methods:

Literature review of recent research on exosomes and HIV-1.
Analysis of studies investigating the source-dependent effects of exosomes on HIV-1.
Synthesis of information on exosome-mediated intercellular signaling in HIV-1 infection.

Main Results:

Exosomes play significant, yet varied, roles in HIV-1 pathogenesis, with the source of the exosome being a critical determinant.
Exosomes can be both manipulated by and influence the spread and impact of HIV-1.
Specific exosomal cargos and their interactions with HIV-1 components are key to understanding these effects.

Conclusions:

The source of exosomes critically defines their impact on HIV-1 infection dynamics.
Understanding exosome-virus interactions is crucial for developing novel therapeutic strategies.
Exosomal cargos hold promise for future interventions aimed at preventing HIV-1 transmission.