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Immunohistochemical analysis of accelerated graft atherosclerosis in cardiac transplantation
Current Surgery
|November 1, 1989
Abstract:
HHT was performed between minimally genetic mismatched inbred strains of rats. There was no evidence of rejection and immunosuppressive therapy was not instituted. Immunohistochemical analysis using peroxidase conjugated monoclonal anti-rat ASMA of cardiac arterioles in which AGAS developed revealed a decreased peroxidase signal. The data suggest that modulation of actin expression in subintimal cells of cardiac arterioles may play a critical role in the pathologic development of AGAS.