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Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Liam G Heaney1, Ratko Djukanovic2, Ashley Woodcock3

  • 1Centre of Infection and Immunity, The Queens's University of Belfast, Belfast, UK.

Thorax
|July 25, 2015
PubMed
Summary

The UK Refractory Asthma Stratification Programme (RASP-UK) aims to improve severe asthma management by identifying patient subgroups using novel biomarkers. This research will enhance understanding of non-Type 2 inflammation and optimize corticosteroid treatment for better therapeutic development.

Keywords:
Asthma Mechanisms

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Area of Science:

  • * Respiratory Medicine
  • * Clinical Immunology
  • * Pharmacology

Background:

  • * Severe asthma management requires improved stratification beyond inflammatory phenotypes.
  • * Understanding pathophysiological mechanisms in non-Type 2 inflammation is limited.
  • * Current studies lack objective assessment of corticosteroid adherence and optimization strategies.

Purpose of the Study:

  • * To explore novel biomarker strategies for stratifying patients with severe asthma.
  • * To objectively assess adherence to corticosteroids (CS) and optimize CS dosing.
  • * To determine the proportion of severe asthma patients with persistent symptoms and non-eosinophilic inflammation post-CS withdrawal.

Main Methods:

  • * The UK Refractory Asthma Stratification Programme (RASP-UK) will employ biomarker analysis.
  • * Objective assessment of adherence to corticosteroids will be performed.
  • * A novel composite biomarker strategy will be examined for CS dose optimization.

Main Results:

  • * Identification of novel biomarker stratification strategies in severe asthma.
  • * Objective data on corticosteroid adherence and its impact on severe asthma.
  • * Quantification of severe asthma patients with persistent symptoms without eosinophilic inflammation.

Conclusions:

  • * RASP-UK will provide crucial insights into severe asthma heterogeneity.
  • * Biomarker-guided stratification will improve clinical management and accelerate new therapy development.
  • * Enhanced understanding of non-Type 2 inflammatory pathways in severe asthma is expected.