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Related Concept Videos

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Framing Effects

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Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
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Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
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Causes of Similarity-Dissimilarity Effect01:26

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The similarity-dissimilarity effect, a fundamental concept in social psychology, explains how interpersonal similarities and differences influence attraction and social interactions. This effect is supported by three key psychological perspectives: balance theory, social comparison theory, and consensual validation.Balance Theory and Cognitive ConsistencyBalance theory, developed by Fritz Heider, posits that individuals seek cognitive consistency in their relationships. When two people share...
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Social Loafing01:37

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Another way in which a group presence can affect performance is social loafing—the exertion of less effort by a person working together with a group. Social loafing occurs when our individual performance cannot be evaluated separately from the group. Thus, group performance declines on easy tasks (Karau & Williams, 1993). Essentially individual group members loaf and let other group members pick up the slack. Because each individual’s efforts cannot be evaluated,...
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Regression Toward the Mean01:52

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
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Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Investigating Wolbachia-Induced Thelytokous Parthenogenesis and Genetic Toolkit Development Through RNA Interference
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The Triggle effect.

Terrance P Snutch1, Gerald W Zamponi2

  • 1Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.

Biochemical Pharmacology
|July 25, 2015
PubMed
Summary
This summary is machine-generated.

Dr. David Triggle pioneered research into ion channel pharmacology, particularly dihydropyridine interactions with L-type calcium channels. His expertise significantly impacted drug discovery at NeuroMed Pharmaceuticals.

Keywords:
Calcium channelsDihydropyridinesNeuroMedPiperazinesZalicus

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Biochemistry

Background:

  • Dr. David Triggle is a distinguished figure in ion channel pharmacology.
  • His career is marked by significant contributions to understanding dihydropyridine interactions with L-type calcium channels.

Discussion:

  • This abstract highlights Dr. Triggle's foundational work in calcium channel pharmacology.
  • It also details his impactful role in advancing the drug discovery platform at NeuroMed Pharmaceuticals, later known as Zalicus.

Key Insights:

  • Pioneering research on dihydropyridine binding to L-type calcium channels.
  • Significant contributions to the drug discovery process at NeuroMed Pharmaceuticals.

Outlook:

  • Further exploration of L-type calcium channel modulation.
  • Continued application of ion channel research in pharmaceutical development.