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Activity of aminoferrocene-based prodrugs against prostate cancer

Margot Schikora1, Alexander Reznikov2, Liudmila Chaykovskaya2

  • 1Friedrich-Alexander-University of Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Organic Chemistry Chair II, Henkestr. 42, 91054 Erlangen, Germany.

Bioorganic & Medicinal Chemistry Letters
|July 25, 2015
PubMed

Keywords:
AminoferroceneIronProdrugProstate cancerReactive oxygen species

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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
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