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Physical exercise for late-life major depression.

M Belvederi Murri1, M Amore2, M Menchetti2

  • 1Martino Belvederi Murri, MD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Mario Amore, MD, PhD, Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Marco Menchetti, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna; Giulio Toni, MD, Cardiology Unit, Ramazzini Hospital, Carpi; Francesca Neviani, MD, PhD, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Matteo Cerri, MD, PhD, Department of Biomedical and Neuromotor Sciences, University of Bologna; Marco B. L. Rocchi, Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; Donato Zocchi, MD, Luigi Bagnoli, MD, primary care physicians, Bologna; Enrico Tam, PhD, Department of Movement and Neurological Sciences, University of Verona; Angela Buffa, MD, PhD, Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Serena Ferrara, PsyD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Mirco Neri, Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; George S. Alexopoulos, MD, PhD, Department of Psychiatry, Weill Cornell Medical College, New York, USA; Stamatula Zanetidou, MD, Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group martino.belvederi@gmail.com.

The British Journal of Psychiatry : the Journal of Mental Science
|July 25, 2015
PubMed
Summary
This summary is machine-generated.

Augmenting sertraline with physical exercise significantly improved remission rates in older adults with major depression. Higher-intensity exercise showed the best results, suggesting exercise is a safe and effective addition to antidepressant therapy.

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Area of Science:

  • Gerontology
  • Psychiatry
  • Clinical Medicine

Background:

  • Late-life major depression presents significant challenges.
  • Physical exercise interventions show promise but require further investigation.

Purpose of the Study:

  • To evaluate the efficacy of augmenting sertraline with physical exercise for treating late-life major depression.

Main Methods:

  • Randomized controlled trial involving 121 patients (aged 46-5 years) with major depression.
  • Three groups: sertraline plus higher-intensity progressive aerobic exercise (S+PAE), sertraline plus lower-intensity non-progressive exercise (S+NPE), and sertraline alone.
  • Primary outcome: remission defined as a Hamilton Rating Scale for Depression score of ≤10.

Main Results:

  • Remission rates were 45% (sertraline alone), 73% (S+NPE), and 81% (S+PAE).
  • The S+PAE group demonstrated a significantly higher remission rate (P = 0.001).
  • S+PAE also showed a shorter time to remission compared to sertraline alone.

Conclusions:

  • Physical exercise, particularly higher-intensity progressive aerobic exercise, is a safe and effective augmentation strategy for antidepressant therapy in late-life major depression.