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Related Concept Videos

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Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Venous Thrombosis I: Introduction01:30

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
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Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
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The wacky hypercoagulable state of malignancy.

Alok A Khorana1

  • 1CLEVELAND CLINIC.

Blood
|July 25, 2015
PubMed
Summary

A new syndrome of severe limb ischemia linked to warfarin was identified in cancer patients with deep vein thrombosis. This condition involves low platelets, high INRs, and ongoing clotting despite anticoagulation.

Area of Science:

  • Hematology
  • Vascular Medicine
  • Oncology

Background:

  • Warfarin is a common anticoagulant used to treat deep vein thrombosis (DVT).
  • Malignancy is a known risk factor for venous thromboembolism and can complicate anticoagulation therapy.

Purpose of the Study:

  • To describe a novel clinical syndrome of warfarin-associated severe venous limb ischemia.
  • To identify characteristics and potential mechanisms of this syndrome in patients with malignancy.

Main Methods:

  • Retrospective case series of 10 patients with malignancy and DVT treated with warfarin.
  • Analysis of clinical data, including platelet counts, international normalized ratios (INRs), and markers of thrombin generation.

Main Results:

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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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  • A distinct syndrome of severe venous limb ischemia occurred in patients after initiating warfarin for DVT.
  • Patients exhibited a decline in platelet counts after heparin cessation, supratherapeutic INRs, and persistent thrombin generation.
  • The syndrome was associated with underlying malignancy.

    • Conclusions:

    • Warfarin may precipitate severe venous limb ischemia in a subset of patients with malignancy and DVT.
    • This syndrome appears linked to heparin-induced thrombocytopenia-like effects and ongoing thrombin generation.
    • Further investigation is needed to understand the pathophysiology and optimize anticoagulation strategies in these high-risk patients.