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Updated: Apr 6, 2026
Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
Published on: October 2, 2015
Subthalamic stimulation: toward a simplification of the electrophysiological procedure
Damien Fetter1, Stephane Derrey, Romain Lefaucheur
1Department of Neurology, Rouen University Hospital and University of Rouen, Rouen, France - david.maltete@chu-rouen.fr.
Background:
The aim of the present study was to assess the consequences of a simplification of the electrophysiological procedure on the post-operative clinical outcome after subthalamic nucleus implantation in Parkinson disease.
Methods:
Microelectrode recordings were performed on 5 parallel trajectories in group 1 and less than 5 trajectories in group 2. Clinical evaluations were performed 1 month before and 6 months after surgery.
Results:
After surgery, the UPDRS III score in the off-drug/on-stimulation and on-drug/on-stimulation conditions significantly improved by 66,9% and 82%, respectively in group 1, and by 65.8% and 82.3% in group 2 (P<0.05). Meanwhile, the total number of words (P<0.05) significantly decreased for fluency tasks in both groups. Motor disability improvement and medication reduction were similar in both groups.
Conclusions:
Our results suggest that the electrophysiological procedure should be simplified as the team's experience increases.
