Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of ultraviolet-induced DNA injury in human skin by p-aminobenzoic acid esters.

S De Rijcke1, M Heenen

  • 1Department of Dermatology, Hospital Erasme, Free University of Brussels, Belgium.

Dermatologica
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidermal kinetic alterations required to generate the psoriatic phenotype: a reappraisal.

Cell proliferation·2010
Same author

[Interest of immunohistochemic markers (Ki67, HMB45, p53) in risk analysis of congenital naevi of little and middle size].

Revue medicale de Bruxelles·2009
Same author

Time-kinetic study of repigmentation in vitiligo patients by tacrolimus or pimecrolimus.

Archives of dermatological research·2009
Same author

[Management of cutaneous toxicities induced by epidermal growth factor receptor inhibitors: a review].

Revue medicale de Bruxelles·2009
Same author

Facial actinic lichen planus following the Blaschko's lines: successful treatment with topical 0.1% pimecrolimus cream.

Journal of the European Academy of Dermatology and Venereology : JEADV·2008
Same author

Black Skin Dermatology Online, from the project to the website: a needed collaboration between North and South.

Journal of the European Academy of Dermatology and Venereology : JEADV·2008

Sunscreens with p-aminobenzoic acid (PABA) esters were found to reduce DNA repair by about 50% in human skin cells. This suggests PABA ester sunscreens may help prevent skin cancer caused by UV radiation.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Photobiology

Background:

  • Ultraviolet (UV) radiation causes DNA damage in skin cells.
  • DNA repair mechanisms are crucial for preventing UV-induced carcinogenesis.
  • Sunscreens aim to protect skin from UV damage.

Purpose of the Study:

  • To evaluate the impact of p-aminobenzoic acid (PABA) ester sunscreen on UV-induced DNA damage.
  • To quantify the effect of PABA ester sunscreen on DNA repair intensity in human epidermal cells.

Main Methods:

  • Human epidermal cells were exposed to UV radiation.
  • The intensity of unscheduled DNA synthesis was measured to assess DNA repair.
  • The effect of a PABA ester-containing sunscreen was evaluated using this method.

Related Experiment Videos

Main Results:

  • UV-induced DNA injury was assessed in human epidermal cells.
  • DNA repair was significantly reduced by approximately 50% in the presence of PABA ester sunscreen.
  • This indicates a substantial inhibition of the DNA repair process.

Conclusions:

  • Sunscreens formulated with p-aminobenzoic acid (PABA) esters may inhibit DNA repair mechanisms.
  • The reduction in DNA repair suggests a potential decrease in photocarcinogenesis.
  • Further research is warranted to confirm the photoprotective efficacy of PABA ester sunscreens.