Principles of Pharmacogenetics: Types of Genetic Variants
Combinatorial Gene Control
Cis-regulatory Sequences
Cis-regulatory Sequences
Single Nucleotide Polymorphisms-SNPs
Pleiotropy
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
Carolina B Meloto1, Samantha K Segall, Shad Smith
1The Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA Department of Prosthesis and Periodontology, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil Department of Medicine, Division of Gastroenterology, College of Medicine, University of Florida, Gainesville, FL, USA Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA Department of Community Dentistry and Behavioral Science, University of Florida, College of Dentistry, and Pain, Research and Intervention Center of Excellence, Clinical and Translational Research Building (CTRB), Gainesville, FL, USA Department of Neural and Pain Sciences, and Brotman Facial Pain Clinic, University of Maryland School of Dentistry, Baltimore, MD, USA Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA Battelle Memorial Institute, Battelle Centers for Public Health Research and Evaluation (CPHRE), Durham, NC, USA National Institute of Environmental Health Sciences, Durham, NC, USA Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
A newly discovered enzyme variant, alpha-COMT, plays a key role in pain signaling. Genetic variations in this variant influence pain sensitivity by affecting dopamine metabolism, not adrenaline.
09:37Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
11:35Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
Published on: August 21, 2016
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