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Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

4.7K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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[Neuroprotection for preterm infants with antenatal magnesium sulphate].

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Related Experiment Video

Updated: Apr 6, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

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[Below 26 gestational week prematurity: What support?].

N Winer1, C Flamant2

  • 1Service de gynécologie-obstétrique, hôpital Mère-Enfant, CHU de Nantes, 38, boulevard Jean-Monnet, 44093 Nantes cedex, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|July 26, 2015
PubMed
Summary
This summary is machine-generated.

Decisions for extremely preterm infants (below 26 weeks gestation) involve complex ethical and medical considerations. Gestational age alone is insufficient for predicting outcomes; prenatal factors and parental wishes are crucial for guiding care.

Keywords:
ConcertationDiscussionEthicalExtreme prematurityExtrême prématuritéManagementMode d’accouchementPrise en chargePronosticRoute of deliveryÉthique

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Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Transcutaneous Microcirculatory Imaging in Preterm Neonates

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Area of Science:

  • Neonatal Intensive Care
  • Perinatal Medicine
  • Bioethics

Context:

  • Management of extremely preterm infants (below 26 weeks gestation) at borderline viability is ethically and medically challenging.
  • Survival rates and outcomes for these infants vary significantly, necessitating careful consideration of available literature and international experiences.
  • Current practices highlight limitations in neonatal intensive care for very preterm infants (24-25 weeks gestation), despite potentially unfavorable neurodevelopmental outcomes.

Purpose:

  • To explore the complexities surrounding intensive care decisions for extremely preterm infants.
  • To emphasize the inadequacy of gestational age as the sole predictor of survival and neurodevelopmental outcomes.
  • To advocate for a multidisciplinary approach that incorporates parental preferences and considers various prenatal factors.

Summary:

  • Gestational age alone is unreliable for predicting survival and neurodevelopmental outcomes in preterm infants.
  • Prenatal factors such as corticosteroid administration, gender, estimated fetal weight, and umbilical Doppler flow are important predictors.
  • Multidisciplinary discussions involving parents are essential for determining active resuscitation or palliative management, respecting individual wishes.

Impact:

  • Highlights the need for individualized counseling and shared decision-making with parents regarding preterm infant care.
  • Underscores the importance of specialized maternofetal centers for managing high-risk pregnancies and births.
  • Addresses the controversial role of delivery route, including cesarean section, in improving survival rates for extremely preterm infants while acknowledging maternal risks.