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Pharmacologic evaluation of cardiovascular reflex responses in migraine patients: lack of central sympathetic
L Munari1, I Milanesi, A Silvani
1Neurologic Institute C. Besta, Milan, Italy.
Functional Neurology
|October 1, 1989
Abstract:
To characterize autonomic imbalance in migraine, we compared the cardiovascular reflex responses of 10 migraineurs and 10 healthy subjects after pharmacological noradrenergic stimulation or inhibition. A battery of 5 autonomic tests was administered on basal conditions as well as after pretreatment with drugs acting at different levels on the noradrenergic pathway: pseudoephedrine, clonidine, guanethidine, indenolol, prazosin. Our data confirm a predominantly sympathetic hypofunction in migraine and provide evidence for an impairment of the central autonomic control.