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Multiple dengue virus types harbored by individual mosquitoes
Bennet Angel1, Annette Angel1, Vinod Joshi1
1Laboratory of Virology & Molecular Biology, Desert Medicine Research Centre, Indian Council of Medical Research, Jodhpur, India.
Acta Tropica
|July 26, 2015
Summary
This study found multiple dengue virus types within single mosquitoes in India, suggesting a novel transmission pathway for Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). This discovery offers new insights into dengue virus epidemiology.
Area of Science:
- Medical Entomology
- Virology
- Infectious Diseases
Background:
- Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) are severe forms of dengue infection.
- Current understanding suggests DHF/DSS result from sequential infections with different dengue virus serotypes.
- The role of mosquitoes in transmitting multiple dengue virus types simultaneously is not fully understood.
Purpose of the Study:
- To investigate the presence of multiple dengue virus types within individual mosquitoes.
- To explore potential vertical transmission of multiple dengue virus types in mosquitoes.
Main Methods:
- Larvae were collected from 31 dengue-endemic towns in Rajasthan, India.
- Laboratory-reared mosquitoes (n=212) were individually tested for dengue virus (DENV) serotypes using RT-PCR.
Main Results:
- Multiple DENV types were detected in 78.7% of the infected individual mosquitoes studied.
- This is the first report demonstrating that single mosquitoes can harbor multiple dengue virus types.
Conclusions:
- Single mosquitoes can be infected with and potentially transmit multiple DENV types.
- This finding may have significant implications for understanding dengue pathogenesis and transmission dynamics.
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