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[Choroid plexus tumours in childhood: Experience in Sant Joan de Déu hospital]
Clara Maria Del Río-Pérez1, Mariona Suñol-Capella2, Ofelia Cruz-Martinez3
1Servicio de Neurocirugía, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Insights
Choroid plexus tumours (CPTs) are rare pediatric brain tumors. Complete resection is the primary treatment, with adjuvant therapy for carcinomas, but outcomes vary by histological type.
Area of Science:
- Neuro-oncology
- Pediatric Pathology
- Neurosurgery
Context:
- Choroid plexus tumours (CPTs) are rare neoplasms, predominantly affecting infants.
- Incidence peaks in the first two years of life, with varied ventricular locations in children versus adults.
- Intracranial hypertension is the most common clinical presentation.
Purpose:
- To review choroid plexus tumours treated at a single institution from 1980 to 2014.
- To analyze demographic, clinical, histological, treatment, and recurrence data.
- To evaluate treatment strategies and patient outcomes.
Summary:
- Eighteen patients with CPTs were analyzed for clinical and histological data.
- Complete surgical resection is the standard treatment.
- Adjuvant therapy is recommended for carcinomas; its role in atypical papillomas is debated, with radiation reserved for recurrences.
Impact:
- Papillomas demonstrate favorable outcomes.
- Atypical papillomas and carcinomas have a poorer prognosis.
- This review informs treatment decisions and prognostic understanding for CPTs.
Abstract:
Choroid plexus tumours are rare, with a peak incidence in the first two years of life. The most common location is the lateral ventricle in children, while in adults it is the fourth ventricle. The most common clinical manifestation is the signs and symptoms of intracranial hypertension. They are histologically classified as plexus papilloma, atypical plexus papilloma, and plexus carcinoma. A review is presented on choroid plexus tumours treated in the Hospital Sant Joan de Déu between 1980 and 2014. A total of 18 patients have been treated. An analysis was made of the demographic, clinical, histological data, treatment, and recurrences. The treatment of choice is complete resection, accompanied by adjuvant therapy in carcinomas. In atypical papillomas, the use of adjuvant therapies is controversial, reserving radiation therapy for recurrences. Papillomas have a good outcome, whereas atypical papillomas and carcinomas outcome is poor.