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Related Concept Videos

Hair Cells01:22

Hair Cells

46.7K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Anatomy of the Ear01:16

Anatomy of the Ear

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Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
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The Cochlea01:13

The Cochlea

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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Bottom-up and Shotgun Proteomics to Identify a Comprehensive Cochlear Proteome
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SHIELD: an integrative gene expression database for inner ear research.

Jun Shen1, Déborah I Scheffer2, Kelvin Y Kwan3

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School Center for Hereditary Deafness, jshen5@partners.org.

Database : the Journal of Biological Databases and Curation
|July 26, 2015
PubMed
Summary
This summary is machine-generated.

The Shared Harvard Inner Ear Laboratory Database (SHIELD) provides accessible gene expression data to advance understanding of hearing and balance. This resource aims to accelerate molecular studies of the inner ear and its associated disorders.

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Area of Science:

  • Inner ear biology
  • Genomics
  • Molecular biology

Background:

  • The inner ear, crucial for hearing and balance, presents challenges for molecular research due to its size and tissue scarcity.
  • Key aspects like mechanotransduction proteins, developmental biology, and genetic causes of hearing/balance disorders remain poorly understood.

Purpose of the Study:

  • To create an integrated resource for inner ear genomic, transcriptomic, and proteomic data.
  • To facilitate research and collaboration by organizing and analyzing accumulated gene expression data.
  • To accelerate discovery in the molecular biology of hearing, balance, and deafness.

Main Methods:

  • Development of the Shared Harvard Inner Ear Laboratory Database (SHIELD).
  • Compilation and integration of five existing inner ear gene expression datasets.
  • Creation of a searchable web interface with online gene pages and downloadable data tables.

Main Results:

  • The SHIELD database integrates experimental data and annotations for the inner ear.
  • It offers two data retrieval options: online viewing or offline data table downloads.
  • Published and unpublished data are made freely available to the research community.

Conclusions:

  • The SHIELD database serves as a valuable, publicly accessible resource for inner ear research.
  • It is expected to significantly accelerate the study of inner ear function and dysfunction.
  • Facilitates research into the genetic basis of hereditary hearing and balance disorders.