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Cytomegalovirus implicated in a case of progressive outer retinal necrosis (PORN)

Maroun Sfeir1

  • 1University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL 33136, USA.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|July 26, 2015
PubMed

Insights

Progressive outer retinal necrosis (PORN), a severe eye condition, can be caused by cytomegalovirus (CMV) in patients with acquired immune deficiency syndrome (AIDS). This case highlights CMV-related PORN and Mycobacterium avium intracellulare duodenitis in uncontrolled HIV.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Virology

Background:

  • Progressive outer retinal necrosis (PORN) is a necrotizing retinopathy often seen in patients with acquired immune deficiency syndrome (AIDS).
  • Varicella-zoster virus is a known cause, but other etiologic agents are possible.
  • Opportunistic infections are common in individuals with uncontrolled human immunodeficiency virus (HIV) infection.

Observation:

  • A case study of a patient with uncontrolled HIV infection.
  • The patient presented with simultaneous opportunistic infections.
  • These included PORN and Mycobacterium avium intracellulare duodenitis.

Findings:

  • Cytomegalovirus (CMV) was identified as the etiologic agent for PORN in this patient.
  • This demonstrates CMV as a cause of PORN, a variant of necrotizing herpetic retinopathy.
  • The co-occurrence of CMV-related PORN and Mycobacterium avium intracellulare duodenitis was observed.

Implications:

  • Highlights the potential role of CMV in PORN, expanding beyond Varicella-zoster virus.
  • Underscores the risk of multiple opportunistic infections in patients with uncontrolled HIV.
  • Emphasizes the importance of identifying specific etiologic agents for effective management of PORN and other infections in immunocompromised individuals.

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