Related Experiment Video
Updated: Apr 6, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
Published on: June 13, 2025
Change in motor function and adverse health outcomes in older African-Americans
Aron S Buchman1, Robert S Wilson2, Sue E Leurgans1
1Rush Alzheimer's Disease Center, Rush University Medical Center, United States; Department of Neurological Sciences, Rush University Medical Center, United States.
Objective:
We tested whether declining motor function accelerates with age in older African-Americans.
Methods:
Eleven motor performances were assessed annually in 513 older African-Americans.
Results:
During follow-up of 5 years, linear mixed-effect models showed that motor function declined by about 0.03 units/year (Estimate, -0.026, p<0.001); about 4% more rapidly for each additional year of age at baseline. A proportional hazard model showed that both baseline motor function level and its rate of change were independent predictors of death and incident disability (all p's<0.001). These models showed that the additional annual amount of motor decline in 85 year old persons at baseline versus 65 year old persons was associated with a 1.5-fold higher rate of death and a 3-fold higher rate of developing Katz disability.
Conclusions:
The rate of declining motor function accelerates with increasing age and its rate of decline predicts adverse health outcomes in older African-Americans.
More Related Videos
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
Related Concept Videos
The Effect of Aging on Tissues
Pharmacodynamics in Geriatric Patients: Effects of Age
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion