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Related Experiment Video

Updated: Apr 6, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
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Gray Matter Volume Decrease Distinguishes Schizophrenia From Bipolar Offspring During Childhood and Adolescence.

Gisela Sugranyes1, Elena de la Serna2, Soledad Romero2

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Journal of the American Academy of Child and Adolescent Psychiatry
|July 27, 2015
PubMed
Summary
This summary is machine-generated.

Children with a parent diagnosed with schizophrenia show reduced gray matter volume. This neurodevelopmental difference appears specific to schizophrenia risk, not bipolar disorder risk, in youth.

Keywords:
bipolar disordermagnetic resonance imagingschizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Schizophrenia and bipolar disorder share neurodevelopmental origins.
  • Distinct neurodevelopmental pathways may exist between these disorders.
  • Understanding these differences is crucial for early intervention.

Purpose of the Study:

  • To comparatively examine gray matter volume in children and adolescents at clinical high risk for schizophrenia or bipolar disorder.
  • To identify specific neurodevelopmental differences associated with familial risk for these disorders.

Main Methods:

  • Structural magnetic resonance imaging (MRI) was used to assess brain gray matter volume.
  • 198 participants (aged 6-17) included offspring of patients with schizophrenia, bipolar disorder, and healthy controls.
  • Analyses included global brain volumes and voxel-based morphometry.

Main Results:

  • Offspring of patients with schizophrenia exhibited reduced total cerebral gray matter volume compared to controls.
  • A significant reduction in gray matter volume was observed in the left inferior frontal cortex/anterior insula in offspring of patients with schizophrenia.
  • No significant gray matter volume differences were found between offspring of patients with bipolar disorder and controls.

Conclusions:

  • Childhood gray matter volume reduction may be specific to the risk for schizophrenia.
  • This finding suggests a potentially greater neurodevelopmental impact of schizophrenia risk during youth.
  • Early neuroimaging may help differentiate neurodevelopmental trajectories in youth at risk for severe mental illness.